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Titanium(IV) isopropoxide is used as a precursor for the preparation of titanium and barium-strontium-titanate thin films. It is useful to make porous titanosilicates and potential ion-exchange materials for cleanup of radioactive wastes. It is an active component of sharpless epoxidation as well as involved in the synthesis of chiral epoxides. In Kulinkovich reaction, it is involved as a catalyst in the preparation of cyclopropanes.
Catalyst for transesterification, avoiding acidic or basic conditions. The reaction is carried out such that one alcohol is removed to displace the equilibrium: Synthesis, 138 (1982); Org. Synth. Coll., 8, 201 (1993). For application to carbamates, including Boc to Cbz conversion, see: J. Org. Chem., 62, 7096 (1997).
For use in the Sharpless enantioselective epoxidation of allylic alcohols, see tert-Butyl hydroperoxide, A13926. For analogous enantioselective oxidation of sulfides to sulfoxides, see Cumene hydroperoxide, L06866. Epoxy alcohols can also be obtained in high yield in one pot by hydroperoxidation of alkenes with singlet oxygen in the presence of Ti(O-i-Pr)4: J. Am. Chem. Soc., 111, 203 (1989).
Also catalyzes the ring-opening of 2,3-epoxy alcohols (e.g. from the above reactions) with various nucleophiles, including amines, thiols, thiolate anions, halides, carboxylates etc. The mild conditions result in increased regioselectivity: J. Org. Chem., 50, 1557 (1985).
See also Dimethylamine hydrochloride, A12133.
For conversion of epoxides to episulfides, see Thiourea, A12828. For use in reductive alkylation of amines, see Sodium cyanoborohydride, 87839. For use in enantioselective synthesis of homoallylic alcohols, see (R)-(+)-1,1'-Bi(2-naphthol), L08305. For reduction of amides to aldehydes, see Diphenylsilane, A10884.
For a brief feature on uses of the reagent, see: Synlett, 2261 (2003).
Khalil, K. M.; El-Khatib, R. M.; Ali, T. T.; Mahmoud, H. A.; Elsamahy, A. A. Titania nanoparticles by acidic peptization of xerogel formed by hydrolysis of titanium(IV) isopropoxide under atmospheric humidity conditions. Powder Technol. 2013, 245, 156-162.
Wanna, N.; Kraithong, T.; Khamnaen, T.; Phiriyawirut, P.; Charoenchaidet, S.; Tantirungrotechai, J. Aluminum-and calcium-incorporated MCM-41-type silica as supports for the immobilization of titanium(IV) isopropoxide in ring-opening polymerization of l-lactide and ε-caprolactone. Catal. Commun. 2014, 45, 118-123.
Hazard Statements: H226-H319-H331-H335-H336
Flammable liquid and vapour. Causes serious eye irritation. Toxic if inhaled. May cause respiratory irritation. May cause drowsiness or dizziness.
Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P261-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P311-P337+P313-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician. If eye irritation persists: Get medical advice/attention. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant