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4426-47-5 - 1-Butylboronic acid, 98% - n-Butaneboronic acid - A13725 - Alfa Aesar

A13725 1-Butylboronic acid, 98%

CAS Number
4426-47-5
Synonyms
n-Butaneboronic acid

Size Price ($) Quantity Availability
1g 24.21
5g 80.96
25g 261.60
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1-Butylboronic acid, 98%

MDL
MFCD00002106
EINECS
224-607-7

Chemical Properties

Formula
CH3CH2CH2CH2B(OH)2
Formula Weight
101.94
Melting point
92-96°
Sensitivity
Air Sensitive & Hygroscopic
Solubility
Soluble in water.

Applications

1-Butylboronic acid is used as a reagent for preparation of volatile derivatives of diols, e.g. carbohydrates, for GC and mass spectrometry and to prepare chiral oxazaborolidines. It is a precursor to unsymmetric borinic acids, which are inhibitors of serine proteases. Can be used as a transport carrier in membrane-based sugar separations and as an analytical reagent in the determination of serum glucose.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. It is hygroscopic in nature. Incompatible with oxidizing agents. Store under dry inert gas.

Literature References

Franck Picard.; Tobias Schulz.; Rolf W. Hartmann. 5-Phenyl substituted 1-methyl-2-pyridones and 4?-substituted biphenyl-4-carboxylic acids. synthesis and evaluation as inhibitors of steroid-5α-reductase type 1 and 2. Bioorganic & Medicinal Chemistry. 2002, 10 (2), 437-448.

Zhao Yongliang.; Zhao Fengying.; Li Qiang.; Gao Deqing. Synthesis, Characterization and Fluorescence Properties of Europium, Terbium Complexes with Biphenyl-4-Carboxylic Acid and o-Phenanthroline. Journal of Rare Earths. 2006, 24 (1), 18-22.

Reagent for preparation of volatile derivatives of diols, e.g. carbohydrates, for GC and mass spectrometry: J. Chromat., 54, 193 (1971); J. Chromat. Sci., 9, 18 (1971); Gas Chromat., 129 (1968).

In combination with (S)-(-)-ɑ,ɑ-Diphenyl­prolinol, L09217, or its enantiomer (9218), oxazaborolidine catalysts are generated in situ, for use in highly enantioselective reductions: Tetrahedron Lett., 33, 4141 (1992). The same system has been employed in the synthesis of chiral monosubstituted oxiranes: Tetrahedron Lett., 34, 5227 (1993). See also (S)-2-Methyl-CBS-oxazaborolidine monohydrate, L09219, and Appendix 5.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1733489
Harmonized Tariff Code
2931.90
TSCA
No

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