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4-Piperidone hydrochloride monohydrate is used in the generation of compound libraries based on sub-reactions of an Ugi multicomponent reaction (MCR).
Margaret M. Faul.; Michael E. Kobierski.; Michael E. Kopach. Green Chemistry Approach to the Synthesis of N-Substituted Piperidones. J. Org. Chem. 2003, 68 (14), 5739-5741.
Luigi Aurelio.; Celine Valant.; Heidi Figler.; Bernard L. Flynn.; Joel Linden.; Patrick M. Sexton.; Arthur Christopoulos.; Peter J. Scammells. 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists. Bioorganic & Medicinal Chemistry. 2009, 17 (20), 7353-7361.
Hazard Statements: H315-H319-H335-H500
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May form combustible dust concentrations in air
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant