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A13761 Phenoxyacetyl chloride, 98%

CAS Number
701-99-5
Synonyms

Stock No. Size Price ($) Quantity Availability
A13761-18 50g 54.20
A13761-30 250g 173.00
A13761-0B 1000g 548.00
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Phenoxyacetyl chloride, 98%

MDL
MFCD00000726
EINECS
211-862-4

Chemical Properties

Formula
C8H7ClO2
Formula Weight
170.60
Boiling Point
225-226°
Flash Point
108°(226°F)
Density
1.235
Refractive Index
1.5340
Storage & Sensitivity
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Solubility
Reacts with water.

Applications

Acylation of D- and DL-WV with phenoxyacetyl chloride, followed by cleavage of the t-butyl ester,afforded the penultimate penicilloic acids. Phenoxyacetyl chloride was used in the synthesis of series of macrocyclic bis-β-lactams, 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester, N-protected guanosine derivatives, useful in RNA synthesis, phenyloxyketene, for cycloaddition to imines leading to β-lactams. Treatment of iminophosphoranes with phenoxyacetyl chloride afforded respectively the trans- and cis-3-(acylamino)-p-lactams. By the oxidative addition of stannous fluoride to allyliodide, with 1, 2-O-isopropylidene-D-glyceraldehyde and phenoxyacetyl chloride results in the predominant formation of erythro homoallylester, which is in turn converted into 2-deoxy-D-ribose. The 4-disubstituted P-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenylhydrazones of ketones with phenoxyacetyl chloride/Et3N in dichloromethane.

Notes

Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, moisture.

Literature References

Ajay K. Bose,; J. C. Kapur,; J. L. Fahey,; M. S. Manhas. Lactams. XXIX. Synthesis of aza analogs of cepham . J. Org. Chem., . 1973, 38(19), 3437-3438.

John C. Sheehan,; Kenneth R. Henery-Logan. The Total Synthesis of Penicillin V. J. Am. Chem. Soc., 1959, 81(12), 3089-3094.

Can be used to protect OH groups. The phenoxyacetate group is 50x more labile to aqueous ammonia than acetate: Tetrahedron Lett., 4273 (1968). It can also be cleaved with methanolic t-BuNH 2 : Chem. Lett., 965 (1982).

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335

Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
607585
Harmonized Tariff Code
2918.99
TSCA
Yes

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