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583-68-6 - 2-Bromo-4-methylaniline, 99% - 4-Amino-3-bromotoluene - 2-Bromo-p-toluidine - A13818 - Alfa Aesar

A13818 2-Bromo-4-methylaniline, 99%

CAS Number
583-68-6
Synonyms
4-Amino-3-bromotoluene
2-Bromo-p-toluidine

Size Price ($) Quantity Availability
10g 37.29
50g 132.71
250g 470.40
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2-Bromo-4-methylaniline, 99%

MDL
MFCD00007635
EINECS
209-515-7

Chemical Properties

Formula
C7H8BrN
Formula Weight
186.06
Melting point
14-16°
Boiling Point
240-242°
Flash Point
>110°(230°F)
Density
1.494
Refractive Index
1.6030
Solubility
Insoluble in water.

Applications

The N-(3, 5-Dichlorophenyl) naphthaldimine was obtained from the reaction of 2-hy- droxynaphthalene-l-carbaldehyde (0.01 mol) with a solution of 2-bromo-4-methylaniline (0.01 mol) in 40 ml of ethanol. Reaction of 2-bromo-4-methylaniline was quite clean, albeit 3,4-diaminotoluene was isolated just in 37% yield after flash chromatography on silica gel. The bromomethylquinoline starting material 16 was synthesized in two steps using an optimized process route by condensing 2-bromo-4-methylaniline.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Renee Aspiotis,; Denis Deschênes,; Daniel Dubé,; Yves Girard,; Zheng Huang,; France Laliberté,; Susana Liu,; Robert Papp,; Donald W. Nicholson,; Robert N. Young.The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors. Bioorganic & Medicinal Chemistry Letters 2010, 20(18), 5502-5505.

A. Elmali,; Y. Elerman,; I. Svoboda and H. Fuess. N-(3,5-Dichlorophenyl)naphthaldimine. Acta Cryst.. 1998, c54 974-976.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H311-H315-H319

Toxic if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P280h-P305+P351+P338-P309-P310-P302+P352

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water.

Other References

Beilstein
1931711
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2921.43
TSCA
Yes
RTECS
XU4300000

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