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Fenofibrate was formulated with n-butyl L-lactate, Tween 80, and a number of cosurfactants, diluted with the water phase (either water or saccharidesolution) and then subjected to a freeze-drying (FD) process to obtain SMEPMS nanosized.
Shen-Fu Lin,; Ying-Chen Chen,; Hsiu-O Ho,; Wei-Yu Huang,; Ming-Thau Sheu,; Der-Zen Liu. Development and characterization of dilutable self-microemulsifying premicroemulsion systems (SMEPMS) as templates for preparation of nanosized particulates. Int J Nanomedicine. 2013, 8 3455-3466..
Shigenobu Miuram,; Lies Dwiarti,; Tomohiro Arimura,; Minako Hoshino,; Liu Tiejun,; Mitsuyasu Okabe .Enhanced production of l-lactic acid by ammonia-tolerant mutant strain Rhizopus sp. MK-96-1196 . Journal of Bioscience and Bioengineering. 2004, 97 (1), 19-23.
Hazard Statements: H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.