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Fenofibrate was formulated with n-butyl L-lactate, Tween 80, and a number of cosurfactants, diluted with the water phase (either water or saccharidesolution) and then subjected to a freeze-drying (FD) process to obtain SMEPMS nanosized.
Shen-Fu Lin,; Ying-Chen Chen,; Hsiu-O Ho,; Wei-Yu Huang,; Ming-Thau Sheu,; Der-Zen Liu. Development and characterization of dilutable self-microemulsifying premicroemulsion systems (SMEPMS) as templates for preparation of nanosized particulates. Int J Nanomedicine. 2013, 8 3455-3466..
Shigenobu Miuram,; Lies Dwiarti,; Tomohiro Arimura,; Minako Hoshino,; Liu Tiejun,; Mitsuyasu Okabe .Enhanced production of l-lactic acid by ammonia-tolerant mutant strain Rhizopus sp. MK-96-1196 . Journal of Bioscience and Bioengineering. 2004, 97 (1), 19-23.
Hazard Statements: H227-H315-H318-H335
Combustible liquid. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.
Precautionary Statements: P210-P235-P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P312-P332+P313-P362-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant