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Precursor to a variety of chelating agents.Salicylaldehyde is used as a precursor to prepare catechol, benzofuran, salicylaldehydimine and 3-carbethoxycoumarin. It is used for colorimetric assay of isoleucine as well as utilized for the determination of primary amine by fluorescence method. It is a key starting material to a various chelating agents. It is used as flavor and fragrance components. Its derivative salicylaldehyde thiosemicarbazone is used for the simultaneous determination of molybdenum and iron by spectrophotometric method.
A convenient method for the racemization of amino acids consists in heating in acetic acid with 0.05 equivalents of an aldehyde, such as salicylaldehyde: J. Org. Chem., 48, 843 (1983).
For a review of the use of circular dichroism studies of salicylidene derivatives of chiral amines, to establish their absolute configurations using the "salicylidene chirality rule", see: Chem. Rev., 83, 359 (1983).
Salem, N. M.; Rashad, A. R.; El Sayed, L.; Foro, S.; Haase, W.; Iskander, M. F. Synthesis, characterization, molecular structure and supramolecular architectures of some copper(II) complexes derived from salicylaldehyde semicarbazone. Inorg. Chim. Acta 2015, 432, 231-242.
Li, K.; Xiang, Y.; Wang, X.; Li, J.; Hu, R.; Tong, A.; Tang, B. Z. Reversible photochromic system based on rhodamine B salicylaldehyde hydrazone metal complex. J. Am. Chem. Soc. 2014, 136 (4), 1643-1649.
Hazard Statements: H227-H302-H315-H319-H335
Combustible liquid. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.