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1-Fluoro-2-nitrobenzene is an intermediate in the synthetic preparations of various pharmaceutical goods.
Elaine K. Fukuda; Robert T. McIverJr. Relative electron affinities of substituted benzophenones, nitrobenzenes, and quinones.J. Am. Chem. Soc.1985, 107 (8), 2291-2296.
The activating effect of aryl halides by o- or p-nitro groups is most pronounced for aryl fluorides, e.g. reacts readily with arylamines in a convenient synthesis of 2-nitrodiarylamines: Synthesis, 215 (1980).
Hazard Statements: H301-H310-H315-H319-H373
Toxic if swallowed. Fatal in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P262-P264b-P270-P280-P301+P310-P302+P350-P305+P351+P338-P310-P314-P330-P332+P313-P361-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Do not get in eyes, on skin, or on clothing. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Gently wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Get medical advice/attention if you feel unwell. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant