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Methyl Pyruvate acts as a potent secretagogue used in the study of stimulus-secretion coupling. Also used in the preparation of quinoxalines as dual phoosphodiesterase 2/10 (PDE2/10) inhibitors. It increases free calcium ion concentration in the cytosol of pancreatic cells. It is used in the preparation of dimethyl 2,3-dimethylenebutanedioate.
G. Bond, P.A. Meheux; A. Ibbotson; P.B. Wells. Origin of enhanced rate in the platinum-catalysed enantioselective hydrogenation of methyl pyruvate. Catalysis Today. 1991, 10 (3), 371-378.
I.M. Sutherland; A. Ibbotson; R.B. Moyes; P.B. Wells. Enantioselective hydrogenation I. Surface conditions during methyl pyruvate hydrogenation catalyzed by cinchonidine-modified platinum/silica (EUROPT-1). Journal of Catalysis. 1990, 125 (1), 77-88.
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