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Ethyl picolinate is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors which is used in the treatment of diabetes. It is also used as pharmaceutical intermediate.
David S.Sigman; Catherine T.Jorgensen. Models for metalloenzymes. Zinc (II)-catalyzed transesterification of N-(.beta.-hydroxyethyl)ethylenediamine by p-nitrophenyl picolinate. J. Am. Chem. Soc. 1972, 94,(5), 1724-1730.
Jennifer Lafont; Adolfo Ensuncho; Rosa M.Dominguez; Alexandra Rotinov; Armando Herize; Jairo Quijano; Gabriel Chuchani. Mechanism of elimination of amino acid derivatives in the gas phase. Pyrolysis kinetics of ethyl picolinate, ethyl 1-methylpipecolinate and picolinic acid. Journal of Physical Organic Chemistry. 2003, 16,(1), 84-88.