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2524-52-9 - Ethyl picolinate, 99% - Ethyl pyridine-2-carboxylate - Picolinic acid ethyl ester - A13973 - Alfa Aesar

A13973 Ethyl picolinate, 99%

CAS Number
2524-52-9
Synonyms
Ethyl pyridine-2-carboxylate
Picolinic acid ethyl ester

Size Price ($) Quantity Availability
25g 57.99
50g 88.80
100g 149.34
250g 300.00
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Ethyl picolinate, 99%

MDL
MFCD00006292
EINECS
219-758-0

Chemical Properties

Formula
C8H9NO2
Formula Weight
151.17
Melting point
1-3°
Boiling Point
239-241°
Flash Point
107°(224°F)
Density
1.120
Refractive Index
1.5105
Solubility
Fully miscible in water.

Applications

Ethyl picolinate is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors which is used in the treatment of diabetes. It is also used as pharmaceutical intermediate.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

David S.Sigman; Catherine T.Jorgensen. Models for metalloenzymes. Zinc (II)-catalyzed transesterification of N-(.beta.-hydroxyethyl)ethylenediamine by p-nitrophenyl picolinate. J. Am. Chem. Soc. 1972, 94,(5), 1724-1730.

 

Jennifer Lafont; Adolfo Ensuncho; Rosa M.Dominguez; Alexandra Rotinov; Armando Herize; Jairo Quijano; Gabriel Chuchani. Mechanism of elimination of amino acid derivatives in the gas phase. Pyrolysis kinetics of ethyl picolinate, ethyl 1-methylpipecolinate and picolinic acid. Journal of Physical Organic Chemistry. 2003, 16,(1), 84-88.

GHS Hazard and Precautionary Statements

Hazard Statements: H319

Causes serious eye irritation.

Precautionary Statements: P305+P351+P338

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Beilstein
122485
Harmonized Tariff Code
2933.39
TSCA
Yes

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