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1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. It is used as a cosmetic agents. It was employed as secondary standard in quantitative proton NMR spectroscopy of pharmaceuticals. It cleaves p-methoxybenzyl protecting group on various alcohols and acids
Gabriel Scalliet; Noellie Journot; Frédéric Jullien, Sylvie Baudino; Jean-Louis Magnard; Stéphanie Channelière; Philippe Vergne; Christian Dumas; Mohammed Bendahmane; J.Mark Cock; Philippe Hugueney. Biosynthesis of the major scent components 3,5-dimethoxytoluene and 1,3,5-trimethoxybenzene by novel rose O-methyltransferases. FEBS Letters. 2002, 523 (1-3), 113-118.
Shuiqin Wu; Naoharu Watanabe; Satoru Mita; Hideo Dohra; Yoshihiro Ueda; Masaaki Shibuya and Yutaka Ebizuka. The Key Role of Phloroglucinol O-Methyltransferase in the Biosynthesis of Rosa chinensis Volatile 1,3,5-Trimethoxybenzene. American Society of Plant Biologists. 2004, 135 (1), 95-102.
Direct dilithiation with n-BuLi/TMEDA gave, after reaction with TMS chloride, the 2,4-disilyl derivative in 85-95% yield: J. Org. Chem., 49, 4657 (1984).
Has been used as the non-transferable group in the conjugate addition of organocuprates. (With Li dialkyl cuprates only one of the two alkyl groups is transferred, with consequent 50% maximum yield.): Chem. Lett., 745 (1988):
Hazard Statements: H301
Toxic if swallowed.
Precautionary Statements: P264-P270-P301+P310a-P321-P405-P501a
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER/doctor Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.