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7803-57-8 - Hydrazine monohydrate, 98+% - A14005 - Alfa Aesar

A14005 Hydrazine monohydrate, 98+%

CAS Number

Size Price ($) Quantity Availability
50g 16.48
250g 39.04
500g 55.62
2500g 222.48
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Hydrazine monohydrate, 98+%


Chemical Properties

Formula Weight
50.06 (32.05anhy)
Melting point
Boiling Point
Flash Point
Refractive Index
Miscible with water and alcohol. Immiscible with chloroform, hydrocarbons and ether.


Hydrazine monohydrate is used as a reducing agent. It is also used in water treatment, especially effluents and industrial boilers, metal treatment and mine extraction process, and synthesis of active ingredients in the pharmaceutical industry like 3-amino-1,2,4-triazole cefazolin, rizatriptan, anastrozole, fluconazole, metazachlor metamitron pyrazole, metribuzin, paclobutrazol, diclobutrazole, propiconazole, and triadimefon. It is involved in the preparation of heterocycles like pyrazoles and pyridazines. It is actively involved in the Wolff-Kishner reduction, which converts the carbonyl group of a ketone into a methylene bridge through a hydrazone intermediate. Further, it is used to cleave N-alkylated phthalimide derivatives. In the Einhorn-Brunner reaction, it reacts with imides to get triazoles.


Special handling precautions required. View MSDS prior to purchase. MSDS are available online at www.alfa.comIncompatible with oxidizing agents, oxygen, copper, organic materials and zinc.

Literature References

Forms stable, water-free solid complexes consisting of one hydrazine molecule associated with one molecule of hydroquinone or two molecules of 4-methoxyphenol. These have potential as replacements for the very hazardous anhydrous hydrazine, e.g. in the solid state reaction with esters to give pure hydrazides: J. Chem. Soc., Chem. Commun., 1531, (1995).

Diimide precursor: for generation of diimide by oxidation with O2, and use in selective reduction of a double bond in the presence of a cyclopropane ring, see: J. Chem. Soc., Chem. Commun., 525 (1973). Review of diimide reductions: Org. React., 40, 91 (1991). See also Hydroxyl­amine-O-sulfonic acid, A12560 .

In the Wolff-Kishner carbonyl to methylene reduction (heating with hydrazine and alkali hydroxide), diethylene glycol is now the usual solvent (the Huang Minlon modification): J. Am. Chem. Soc., 68, 2487 (1946); Org. Synth. Coll., 4, 510 (1963). The reduction has also been performed at ambient temperature by the use of KO-t-Bu in DMSO: J. Am. Chem. Soc., 84, 1734 (1962). See also Isatin, A12468 for an analogous reduction.

In the presence of Rh on carbon, nitrobenzene is selectively reduced to phenylhydroxylamine: Org. Synth. Coll., 8, 16 (1993).

For a brief feature on uses of the reagent in synthesis, see: Synlett, 2445 (2004).

Shiraishi, Y.; Hirakawa, H.; Hirai, T. Photocatalytic Hydrogenation of Nitroaromatics to Anilines on Silica-Supported Iron Oxides with Hydrazine Monohydrate as a Reductant. J. Chem. Eng. Jpn. 2015, 48 (2), 141-146.

Sun, J. K.; Xu, Q. Metal Nanoparticles Immobilized on Carbon Nanodots as Highly Active Catalysts for Hydrogen Generation from Hydrazine in Aqueous Solution. Chem. Cat. Chem. 2015, 7 (3), 526-531.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H310-H330-H317-H350-H314-H318-H400-H410-H227

Toxic if swallowed. Fatal in contact with skin. Fatal if inhaled. May cause an allergic skin reaction. May cause cancer. Causes severe skin burns and eye damage. Causes serious eye damage. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects. Combustible liquid.

Precautionary Statements: P210-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
Packing Group
Harmonized Tariff Code


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