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D-Mannitol is used in the determination of glomerular filtration rate. It is used as an inert osmotic control substance. Further, it is used in the treatment of oliguric renal failure. It is also used as a sweetener for people with diabetes, in chewing gums and acts as an adulterant for heroin, methamphetamines and cocaine. It finds application as a research tool in cell biological studies, usually to control osmolarity.
Wang, C.; Dong, L.; Niu, M.; Liu, M.; Sun, D.; Wang, B.; Han, J. Enthalpic Interactions of HMBA with Glycine, l-Alanine, and l-Serine in Aqueous d-Mannitol Solutions at 298.15 K. J. Chem. Eng. Data 2015, 60 (3), 845-855.
Goel, M.; Marsh, E. N. G.; Chen, Z.; Abbott, N. L. Comparison of the influence of humidity and d-mannitol on the organization of tetraethylene glycol-terminated self-assembled monolayers and immobilized antimicrobial peptides. Langmuir 2014, 30 (24), 7143-7151.