Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

A14079 Tetronic acid, 96%

CAS Number

Stock No. Size Price ($) Quantity Availability
A14079-06 5g 89.90
A14079-14 25g 337.00
Add to Cart Bulk/Specialty Print Quote View Item

Tetronic acid, 96%


Chemical Properties

Formula Weight
Melting point
ca 140° dec.
Storage & Sensitivity
Ambient temperatures.
Soluble in water, dimethyl sulfoxide, acetonitrile and alcohol.


Tetronic acid is used as a precursor of a variety of substituted and ring-fused furans and butenolides. It is an acidic building block for heterocyclic compounds for medicinal applications. It is used for selective O-alkyaltion reactions involving cesium fluoride. It is also used to prepare 3H-furo[3,4-b]quinolin-1-one by reacting with 2-amino-benzaldehyde.


Incompatible with strong oxidizing agents and strong alkalis (bases).

Literature References

Equivalent to the -lactone of 4-hydroxyacetoacetic acid.

Selective O-alkylation is promoted by CsF under mild conditions: Synlett, 843 (1995).

Versatile precursor of a variety of substituted and ring-fused furans and butenolides; see, e.g.: J. Org. Chem., 48, 1914 (1983); Synthesis, 155 (1996).

Li, X. K.; Xiong, F.; Shen, Z. Y.; Zhang, S. P.; Zhou, Y. H.; Xu, M. L.; Zhou, Z. Q. Unexpected Facile Synthesis of Tetronic Acid During the Research on Stereospecific Total Synthesis of (+)-Biotin Starting from D-Erythorbic Acid as Chiral Pool. Asian J. Chem. 2015, 27 (5), 1957.

Chopin, N.; Yanai, H.; Likawa, S.; Pilet, G.; Bouillon, J. P.; Médebielle, M. A Rapid Entry to Diverse gamma-Ylidenetetronate Derivatives through Regioselective Bromination of Tetronic Acid Derived gamma-Lactones and Metal-Catalyzed Postfunctionalization. Eur. J. Org. Chem. 2015, 2015 (28), 6259-6269.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code


Recently Viewed


Life Science

Metals & Materials


Analytical & Labware