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A14152 2-Mercaptopyridine N-oxide, 99%

CAS Number
2-Pyridinethiol N-oxide

Stock No. Size Price ($) Quantity Availability
A14152-06 5g 62.80
A14152-14 25g 160.00
A14152-22 100g 545.00
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2-Mercaptopyridine N-oxide, 99%


Chemical Properties

Formula Weight
Melting point
Storage & Sensitivity
Air Sensitive. Light Sensitive. Store under Nitrogen. Ambient temperatures.
Soluble in tris-hydrochloric acid.


2-Mercaptopyridine N-oxide is used in ratiometric fluorescence imaging of intracellular zinc ions in mammalian cultures. It is used in the radical coupling of benzoyl derivatives of 2-deoxy-D-ribose, with heterocyclic bases to give C-nucleosides. It acts as a ligand and form coordination complexes with palladium chloride. It is a precursor to O-acyl thiohydroxamates. Further, it serves as an antifungal agent. In addition to this, it is used in the preparation of 1-oxa-2-oxo-3-thia-indolizinium chloride by reaction with carbonyl dichloride.


Incompatible with strong oxidizing agents and strong bases.

Literature References

Thermal decomposition of O-acyl derivatives generates alkyl radicals: Tetrahedron Lett., 26, 5939, 5943 (1985). Reaction with Bu3SnH leads to decarboxylation: J. Chem. Soc., Chem. Commun., 939 (1983); Tetrahedron, 41, 3901 (1985):

This sequence has also been applied to the esters with amino acids, prepared by mixed anhydride coupling using isobutyl chloroformate: J. Chem. Soc., Chem. Commun., 1298 (1984). The active esters have also been applied to formatiion of amides and peptides: Tetrahedron, 52, 9347, 9367 (1996).

Decomposition of the ester in CCl4 gives the alkyl chloride: Tetrahedron Lett., 24, 4979 (1983), in BrCCl3 the alkyl bromide, and in CHI3, the iodide: Tetrahedron, 43, 4321 (1987); Org. Synth., 75, 124 (1997). Similarly, decarboxylation in the presence of Diphenyl­ diselenide, A13919 , results in phenylselenoethers, which can be used to introduce a double bond via selenoxide elimination: Heterocycles, 25, 449 (1987); J. Org. Chem., 55, 2282 (1990).

Has been used in the radical coupling of benzoyl derivatives of 2-Deoxy-D-ribose, A11990 , with heterocyclic bases to give C-nucleosides: Chem. Lett., 1673 (1992).

Bretti, C.; Cigala, R. M.; Crea, F.; De Stefano, C.; Lando, G.; Sammartano, S. Thermodynamics of Zn2+ 2-mercaptopyridine-N-oxide and 2-hydroxypyridine-N-oxide interactions: Stability, solubility, activity coefficients and medium effects. J. Mol. Liq. 2015, 211, 876-884.

Bretti, C.; Cigala, R. M.; Lando, G.; Milea, D.; Sammartano, S. Some Thermodynamic Properties of Aqueous 2-Mercaptopyridine-N-Oxide (Pyrithione) Solutions. J. Solution Chem. 2014, 43 (6), 1093-1109.

Zhang, G. Polymorphism in unusual one-dimensional coordination polymers based on cadmium(II) and 2-mercaptopyridine N-oxide. CrystEngComm 2013, 15 (33), 6453-6456.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

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