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A14177 2-Amino-4-methylpyridine, 98%

CAS Number
695-34-1
Synonyms
2-Amino-4-picoline
4-Methyl-2-pyridinamine

Stock No. Size Price ($) Quantity Availability
A14177-14 25g 19.20
A14177-22 100g 28.50
A14177-36 500g 118.00
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2-Amino-4-methylpyridine, 98%

MDL
MFCD00006321
EINECS
211-780-9

Chemical Properties

Formula
C6H8N2
Formula Weight
108.14
Melting point
97-101°
Boiling Point
231°
Flash Point
118°(244°F)
Storage & Sensitivity
Hygroscopic. Ambient temperatures.
Solubility
Soluble in water (41 mg/ml at 20°C), lower alcohols (slightly), chloroform, ethyl acetate, and DMF.

Applications

2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl­pyridinium 2-hy­droxy­benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.

Notes

Hygroscopic. Incompatible with oxidizing agents and moisture. Store under dry inert gas. Protect from humidity and water. Store at -20°C.

Literature References

Madhukar Hemamalini; Hoong-Kun Fun. 2-Amino-4-methyl-pyridinium 2-hy-droxy-benzoate. Acta Crystallographica Section E.2010, 66 (Pt 8), o2151-o2152.

W S Faraci; A A Nagel; K A Verdries; L A Vincent; H Xu; L E Nichols; J M Labasi; E D Salter; E R Pettipher. 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo. British Journal of Pharmacology.1996, 119 (6), 1101-1108.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H311-H315-H319-H335

Toxic if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P361-P363-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,466
Beilstein
107066
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.39
TSCA
Yes
RTECS
TJ5150000

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