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288-13-1 - 1H-Pyrazole, 98% - A14186 - Alfa Aesar

A14186 1H-Pyrazole, 98%

CAS Number
288-13-1
Synonyms

Size Price ($) Quantity Availability
25g 42.95
100g 120.15
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1H-Pyrazole, 98%

MDL
MFCD00005234
EINECS
206-017-1

Chemical Properties

Formula
C3H4N2
Formula Weight
68.08
Melting point
66-70°
Boiling Point
186-188°
Sensitivity
Hygroscopic
Solubility
Soluble in water.

Applications

1H-Pyrazole is used as a ligand in the preparation of organometallic compounds. The derivatives of Pyrazole are used in medicine, for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities.

Notes

Hygroscopic. Store in cool, dry place in tightly closed containers. Store away from oxidizing agent and water/moisture.

Literature References

Michael S. Bernatowicz; Youling Wu; Gary R. Matsueda. 1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis. J. Org. Chem. 1992, 57 (8), 2497-2502.

Adnan A. Bekhit; Hayam M.A. Ashour; Yasser S. Abdel Ghany; Alaa El-Din A. Bekhit; Azza Baraka. Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. European Journal of Medicinal Chemistry. 2008, 43 (3), 456-463.

Forms a complex with Pyridinium chlorochromate, A11752, which allows the selective oxidation of allylic alcohols in the presence of non-allylic alcohols: Lipids, 19, 550 (1984).

Can be protected on nitrogen by hydroxymethylation with paraformaldehyde, permitting 3-lithiation with t-BuLi: Tetrahedron, 45, 4253 (1989).

GHS Hazard and Precautionary Statements

Hazard Statements: H361-H302-H315-H319-H335

Suspected of damaging fertility or the unborn child. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P201-P261-P280-P281-P305+P351+P338-P304+P340-P362-P301+P312-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,7960
Beilstein
103775
Harmonized Tariff Code
2933.19
TSCA
Yes
RTECS
UQ4900000

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