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Chlorodiphenylphosphine is used to introduce the diphenylphosphinyl moiety by aryl ortho-lithiation. It is also used as an intermediate to make antioxidants, flame retardants, stabilizers, catalysts, photoinitiators, and optical brighteners. Used as a halogenation reagent for the conversion of alcohols into halides, in the preparation of solid-phase reagent for the conversion of alcohols to alkyl halides.
Mehran Maleki; Allen Miller; O.William Lever Jr. Preparation of α-oxygenated phosphine oxides from chlorodiphenylphosphine. Tetrahedron Letters. 1981, 22 (4), 365-368.
Edward H. Wong; Fontaine C. Bradley. Hydrolysis of chlorodiphenylphosphine complexes of molybdenum and palladium. Inorg. Chem. 1981, 20 (7), 2333-2335.
Reacts with Li metal in liquid ammonia to give the Li diphenylphosphide: Tetrahedron Lett., 21, 3535 (1980). Reaction with vinyl lithium intermediates from the reaction of alkyllithiums with sulfonylhydrazones (see p-Toluenesulfonyl hydrazide, A13529) gives vinylphosphines: Tetrahedron Lett., 22, 4619 (1981).
Hazard Statements: H290-H302-H314-H335
May be corrosive to metals. Harmful if swallowed. Causes severe skin burns and eye damage. May cause respiratory irritation.
Precautionary Statements: P234-P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P390-P501c
Keep only in original container. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Absorb spillage to prevent material damage. Dispose of contents/ container to an approved waste disposal plant