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1,4-Dibromo-2,5-difluorobenzene has been used in the preparation of 1,2,4,5-tetrakis(phosphino)-3,6-difluorobenzenes and poly(2,5-difluoro-2?,5?-didodecyl-4,4?-biphenylylene.
Kongprakaiwoot N, et al. New synthetic route to polyphosphine ligands bearing 1,2,4,5-tetrakis (phosphino) benzene framework: structural characterizations of 1, 4-(PPh2)2-2, 5-(PR2)2-C6F2(R= Ph, iPr, Et). J. Organomet. Chem. 2004, 689 (21), 3350-56.
Kowitz C; and Wegner Gl. Functionalized poly-and oligo-phenylenes: Variations on the Suzuki cross-coupling of functionalized aryl dibromides with the 1, 3-propanediol diester of 2, 5-dialkyl-1, 4-phenylenediboronic acid. Tetrahedron. 1997, 53 (45), 15553-74.
For discussion of reaction with n-BuLi, including formation of dibenzyne, see: Org. Synth., 75, 201 (1997); see also 1,2,4,5-Tetrabromobenzene, L13539.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant