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4-Isopropoxybenzoic acid is used to prepare 5-(4-isopropoxyphenyl)-N-phenyl-1,3,4-thiadiazol-2-amine by reacting with N-phenylhydrazinecarbothioamide in the presence of phosphorusoxychloride.
Neubauer, S.; Rechenmacher, F.; Brimioulle, R.; Di Leva, F. S.; Bochen, A.; Sobahi, T. R.; Schottelius, M.; Novellino, E.; Mas-Moruno, C.; Marinelli, L.; Kessler, H. Pharmacophoric Modifications Lead to Superpotent alphavbeta3 Integrin Ligands with Suppressed alpha5beta1 Activity. J. Med. Chem. 2014, 57 (8), 3410-3417.
Croxall, W. J.; Sowa, F. J.; Nieuwland, J. A. Organic Reactions with Boron Fluoride. XI. The Condensation of Propylene with m-and p-Hydroxybenzoic Acids. J. Am. Chem. Soc. 1935, 57 (9), 1549-1551.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant