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Nickel(II) chloride is used in electroplating and as a catalyst for organic conversions, for example in chemo-selective thioacetalization of aldehydes. In combination with lithium aluminum hydride, it serves as a reducing agent for alkenes, alkynes, and organic halides; it can cleave N-O bond and open epoxides. It is used to prepare a wide array of complexes since water ligands can be easily replaced by amines, thioether, ammonia, and thiolates. It is a precursor to several nickel-phosphine complexes, such as bis(triphenylphosphine)nickel(II) chloride, which are used in alkyne trimerizations, carbonylations, and as catalysts in organic reactions such as Suzuki-Miyaura cross coupling reactions as an alternative to palladium(0) catalysts. It is the precursor to acetylacetonate complex of Ni, used for producing 1,5-cyclooctadiene complex, an important reagent in organonickel chemistry. It can be used to prepare the sandwich compound nickelocene through dimethoxyethane complex of nickel chloride.
In combination with Zn, effects selective reduction of benzaldehydes to benzyl alcohols, ɑß-enones to saturated ketones, and nitroarenes to anilines: Chem. Pharm. Bull., 38, 2097 (1990).
Catalyst for Suzuki cross-coupling of arylboronic acids with aryl halides under mild conditions: Tetrahedron Lett., 43, 4009 (2002).
For a brief feature on uses of NiCl2 and its hydrate in synthesis, see: Synlett, 279 (2003).
Refat, S. M.; El-Deen, I. M.; Zein, M. A.; Adam, A. M. A; Mohamed I. Kobeasy , M. Spectroscopic, Structural and Electrical Conductivity Studies of Co(II), Ni(II) and Cu(II) Complexes derived from 4- Acetylpyridine with Thiosemicarbazide. Int. J. Electrochem. Sci. 2013, 8, 9894-9917.
Dhakras, D.; Borkar, V.; Ogale, S.; Jog, Y. Enhanced piezoresponse of electrospun PVDF mats with a touch of nickel chloride hexahydrate salt. Nanoscale 2012, 4, 752-756.
Hazard Statements: H301-H331-H315-H334-H317-H341-H350-H360-H372
Toxic if swallowed. Toxic if inhaled. Causes skin irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Suspected of causing genetic defects. May cause cancer. May damage fertility or the unborn child. Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements: P201-P273-P309+P311-P501a
Obtain special instructions before use. Avoid release to the environment. IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. Dispose of contents/container in accordance with local/regional/national/international regulations.