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Nickel(II) chloride is used in electroplating and as a catalyst for organic conversions, for example in chemo-selective thioacetalization of aldehydes. In combination with lithium aluminum hydride, it serves as a reducing agent for alkenes, alkynes, and organic halides; it can cleave N-O bond and open epoxides. It is used to prepare a wide array of complexes since water ligands can be easily replaced by amines, thioether, ammonia, and thiolates. It is a precursor to several nickel-phosphine complexes, such as bis(triphenylphosphine)nickel(II) chloride, which are used in alkyne trimerizations, carbonylations, and as catalysts in organic reactions such as Suzuki-Miyaura cross coupling reactions as an alternative to palladium(0) catalysts. It is the precursor to acetylacetonate complex of Ni, used for producing 1,5-cyclooctadiene complex, an important reagent in organonickel chemistry. It can be used to prepare the sandwich compound nickelocene through dimethoxyethane complex of nickel chloride.
In combination with Zn, effects selective reduction of benzaldehydes to benzyl alcohols, ɑß-enones to saturated ketones, and nitroarenes to anilines: Chem. Pharm. Bull., 38, 2097 (1990).
Catalyst for Suzuki cross-coupling of arylboronic acids with aryl halides under mild conditions: Tetrahedron Lett., 43, 4009 (2002).
For a brief feature on uses of NiCl2 and its hydrate in synthesis, see: Synlett, 279 (2003).
Refat, S. M.; El-Deen, I. M.; Zein, M. A.; Adam, A. M. A; Mohamed I. Kobeasy , M. Spectroscopic, Structural and Electrical Conductivity Studies of Co(II), Ni(II) and Cu(II) Complexes derived from 4- Acetylpyridine with Thiosemicarbazide. Int. J. Electrochem. Sci. 2013, 8, 9894-9917.
Dhakras, D.; Borkar, V.; Ogale, S.; Jog, Y. Enhanced piezoresponse of electrospun PVDF mats with a touch of nickel chloride hexahydrate salt. Nanoscale 2012, 4, 752-756.
Hazard Statements: H301-H315-H317-H319-H331-H334-H341-H350i-H360D-H372
Toxic if swallowed. Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation. Toxic if inhaled. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of causing genetic defects. May cause cancer by inhalation. May damage the unborn child. Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements: P201-P202-P260-P264b-P270-P271-P272-P280-P281-P285-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P311-P330-P333+P313-P337+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. In case of inadequate ventilation wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Call a POISON CENTER or doctor/physician. Rinse mouth. If skin irritation or rash occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant