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100-02-7 - 4-Nitrophenol, 99% - A14376 - Alfa Aesar

A14376 4-Nitrophenol, 99%

CAS Number
100-02-7
Synonyms

Size Price ($) Quantity Availability
250g 20.39
1000g 49.75
5000g 208.06
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4-Nitrophenol, 99%

MDL
MFCD00007331
EINECS
202-811-7

Chemical Properties

Formula
C6H5NO3
Formula Weight
139.11
Melting point
110-115°
Boiling Point
279° dec.
Flash Point
169°(336°F)
Density
1.480
Sensitivity
Light Sensitive
Solubility
Freely soluble in alcohol, chloroform, ether. Freely soluble in acetone. Slightly soluble in water.

Applications

4-Nitrophenol is used as a precursor to prepare phenetidine, acetophenetidne and pH indicator. Its carboxylate ester derivatives are involved as an active component for the construction of amide moieties in peptide synthesis. It is used as an intermediate in the synthesis of paracetamol and N-acetyl-p-aminophenol dyestuffs.

Notes

Incompatible with strong oxidizing agents and strong bases.

Literature References

Acid-base indicator: pH 5.6 - 7.6.

Forms active esters with N-protected amino acids, useful in peptide synthesis; see, for example: J. Org. Chem., 62, 1356 (1997). For peptide reagents, see Appendix 6.

Suzuki-type coupling of the triflate with various arylboronic acids gives biaryl derivatives: Tetrahedron, 45, 6679 (1984). For an example of Stille coupling of the triflate with an arylstannane, catalyzed by trans-Dichlorobis(triphenyl­phosphine)­palladium(II)­, 10491, see: Org. Synth. Coll., 9, 553 (1998).

/n

Ye, W.; Yu, J.; Zhou, Y.; Gao, D.; Wang, D.; Wang, C.; Xue, D. Green synthesis of Pt-Au dendrimer-like nanoparticles supported on polydopamine-functionalized graphene and their high performance toward 4- nitrophenol reduction. Appl. Catal., B 2015, 181, 371-378.

Chaudhary, S.; Kumar, S.; Mehta, S. K. Glycol modified gadolinium oxide nanoparticles as a potential template for selective and sensitive detection of 4-nitrophenol. J. Mater. Chem. C 2015, 3 (34), 8824-8833.

GHS Hazard and Precautionary Statements

Hazard Statements: H373-H302-H312-H332

May cause damage to organs through prolonged or repeated exposure. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Precautionary Statements: P260-P261-P280-P264-P304+P340-P301+P312-P312-P363-P322-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Specific measures (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6621
Beilstein
1281877
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2908.99
TSCA
Yes
RTECS
SM2275000

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