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6-Azauracil (6-AU) is used as a growth inhibitor of various microorganisms via depletion of intracellular GTP and UTP nucleotide pools. 6-Azauracil has been widely used in investigations on modulation of transcription, especially in yeast models.
Françoise Exinger and François Lacroute. 6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae.Current Genetics.,1992,22(1), 9-11.
J. Škoda.; V. F. Hess and F. Šorm. Production of 6-azauracil riboside by Escherichia coli growing in the presence of 6-azauracil.Collect. Czech. Chem. Commun.,1957,22(4), 1330-1333.
Hazard Statements: H301-H315-H319-H335-H361d
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Suspected of damaging the unborn child.
Precautionary Statements: P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P337+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant