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1076-38-6 - 4-Hydroxycoumarin, 98+% - A14394 - Alfa Aesar

A14394 4-Hydroxycoumarin, 98+%

CAS Number
1076-38-6
Synonyms

Size Price ($) Quantity Availability
100g 40.86
500g 125.60
2500g 494.40
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4-Hydroxycoumarin, 98+%

MDL
MFCD00006856
EINECS
214-060-2

Chemical Properties

Formula
C9H6O3
Formula Weight
162.14
Melting point
ca 213° dec.
Solubility
Soluble in ethanol and dimethyl formamide. Insoluble in water.

Applications

4-Hydroxycoumarin is involved in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents and strong bases.

Literature References

M. R. HADLER.; R. S. SHADBOLT. Novel 4-hydroxycoumarin anticoagulants active against resistant rats. Nature. 1975, 253 275 - 277.

A. M. El-Agrody.; M. S. Abd El-Latif.; N. A. El-Hady.;A. H. Fakery.; A. H. Bedair. Heteroaromatization with 4-Hydroxycoumarin Part II: Synthesis of Some New Pyrano[2,3-d]pyrimidines, [1,2,4]triazolo[1,5-c]pyrimidines and Pyrimido[1,6-b]-[1,2,4]triazine Derivatives. Molecules. 2001, 6 (6), 519-527.

Like 4-Hydroxy-6-methyl-2-pyrone, L11457, can participate in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans: Tetrahedron, 62, 3016 (2006). For reaction scheme, see: tert-Butyl­ isocyanide, L19747.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
129768
Harmonized Tariff Code
2932.20
TSCA
Yes
RTECS
DJ3100000

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