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Bromoacetic acid is used in organic synthesis and as an alkylating agent. It is also used as a biochemical for proteomics research. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, dyes and agrochemicals.
E.A. Barnard.; W.D. Stein. The histidine residue in the active centre of ribonuclease: I. A specific reaction with bromoacetic acid. Journal of Molecular Biology. 1959, 1 (4-5), 339-349.
Philip J. Elving.; Isadore Rosenthal.; Marilyn Koll Kramer. Polarographic Behavior of Organic Compounds. IX. Iodoacetic Acid and the Bromoacetic Acids. J. Am. Chem. Soc. 1951, 73 (4), 1717-1722.
Reaction with a dialkyl phosphite followed by an aldehyde has been used in a convenient one-pot synthesis of acrylic acids: J. Org. Chem., 46, 2514 (1981). For examples with reaction schemes, see Chloroacetic acid, A11482 and 2-Bromopropionic acid, A17569.
Hazard Statements: H301-H311-H331-H314-H317
Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes severe skin burns and eye damage. May cause an allergic skin reaction.
Precautionary Statements: P260u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
IF SWALLOWED: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.