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A14409 Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water

CAS Number
499-80-9
Synonyms
Lutidinic acid

Stock No. Size Price ($) Quantity Availability
A14409-06 5g 54.50
A14409-14 25g 218.00
A14409-22 100g 733.00
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Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water

MDL
MFCD00149413
EINECS
207-892-2

Chemical Properties

Formula
C7H5NO4
Formula Weight
167.12
Melting point
ca 245° dec.
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water at 20°C 4.5 g/L.

Applications

It is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. It blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,3 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), It modulates hypoxia inducing factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase.8 2,4-PDCA also affects and is translocated by organic anion transporters.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Line H Kristensen, et al. Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.FEBS J.,2012,279(11), 1905-1914.

Koski, M.K, et al.The active site of an algal prolyl 4-hydroxylase has a large structural plasticity. Biol Chem.,2007,282(51), 37112-37123.

Mackeen, et al. Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry. J Proteome Res.,2010,9(8), 4082-4092.

Other References

Beilstein
131631
Harmonized Tariff Code
2933.39
TSCA
Yes

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