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Useful building block in the synthesis of a variety of heterocyclic molecules. For reaction with nitroacetonitrile in a high-yield synthesis of 6-amino-3-cyano-5-nitro-2-pyridone, see: Synthesis, 835 (1991). With ethyl mercaptoacetate, 3-amino-4-cyanothiophene-2-carboxylate is formed in high yield: Synthesis, 1056 (1982). With thiouronium salts, 2-alkylthio-4-amino-5-cyanopyrimidines are obtained: Helv. Chim. Acta, 81, 646 (1998)./n
Has also been used in the synthesis of ortho-amino benzonitrile derivatives by cyclization with active methylene compounds: Monatsh. Chem., 120, 891 (1989)./n
Hazard Statements: H301-H311-H317-H331-H334-H335
Toxic if swallowed. Toxic in contact with skin. May cause an allergic skin reaction. Toxic if inhaled. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P272-P280-P285-P301+P310-P302+P352-P304+P340-P311-P312-P330-P333+P313-P361-P363-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. In case of inadequate ventilation wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation or rash occurs: Get medical advice/attention. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant