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A14452 Trimethylene oxide, 97%

CAS Number
503-30-0
Synonyms
Oxetane

Stock No. Size Price ($) Quantity Availability
A14452-06 5g 59.70
A14452-14 25g 248.00
A14452-22 100g 837.00
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Trimethylene oxide, 97%

MDL
MFCD00005167
EINECS
207-964-3

Chemical Properties

Formula
C3H6O
Formula Weight
58.08
Melting point
-97°
Boiling Point
49-50°
Flash Point
-28°(-18°F)
Density
0.891
Refractive Index
1.3930
Storage & Sensitivity
Keep Cold.
Solubility
Soluble in water.

Applications

Trimethylene oxide useful for the synthesis of 3-substituted propanols by reaction with Grignards or organolithiums in the presence of CuBr.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature is 2 - 8°C. It is hygroscopic in nature and sensitive to air. Store under inert gas.

Literature References

Scott Searles. The Reaction of Trimethylene Oxide with Grignard Reagents and Organolithium Compounds. J. Am. Chem. Soc. 1951, 73 (1), 124-125.

Fouad Fleyfel.; J. Paul Devlin. FT-IR spectra of 90 K films of simple, mixed, and double clathrate hydrates of trimethylene oxide, methyl chloride, carbon dioxide, tetrahydrofuran, and ethylene oxide containing decoupled water-d2. J. Phys. Chem. 1988, 92 (3), 631-635.

3-Carbon fragment, useful for the synthesis of 3-substituted propanols by reaction with Grignards: J. Am. Chem. Soc., 73, 124 (1951), or organolithiums in the presence of CuBr: Tetrahedron Lett., 1095 (1976).

Reaction with K metal: 18-crown-6 complex provides a one pot metallation reaction yielding a comparatively stable product for use in further metallation reactions: J. Chem. Soc., Chem. Commun., 1513 (1991).

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H302+H312+H332

Highly flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Precautionary Statements: P210-P233-P240-P241-P242-P243-P261-P264b-P270-P271-P280-P301+P312-P303+P361+P353-P304+P340-P312-P330-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Rinse mouth. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,9715
Beilstein
102382
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2932.99
TSCA
Yes
RTECS
RQ6825000

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