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Trimethylene oxide useful for the synthesis of 3-substituted propanols by reaction with Grignards or organolithiums in the presence of CuBr.
Scott Searles. The Reaction of Trimethylene Oxide with Grignard Reagents and Organolithium Compounds. J. Am. Chem. Soc. 1951, 73 (1), 124-125.
Fouad Fleyfel.; J. Paul Devlin. FT-IR spectra of 90 K films of simple, mixed, and double clathrate hydrates of trimethylene oxide, methyl chloride, carbon dioxide, tetrahydrofuran, and ethylene oxide containing decoupled water-d2. J. Phys. Chem. 1988, 92 (3), 631-635.
3-Carbon fragment, useful for the synthesis of 3-substituted propanols by reaction with Grignards: J. Am. Chem. Soc., 73, 124 (1951), or organolithiums in the presence of CuBr: Tetrahedron Lett., 1095 (1976).
Reaction with K metal: 18-crown-6 complex provides a one pot metallation reaction yielding a comparatively stable product for use in further metallation reactions: J. Chem. Soc., Chem. Commun., 1513 (1991).
Hazard Statements: H225-H302-H312-H332
Highly flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
Precautionary Statements: P210-P261-P280-P303+P361+P353-P304+P340-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Dispose of contents/container in accordance with local/regional/national/international regulations.