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A14472 Pentafluoropropionic anhydride, 98%

CAS Number
356-42-3
Synonyms
Perfluoropropionic anhydride

Stock No. Size Price ($) Quantity Availability
A14472-06 5g 30.00
A14472-14 25g 106.00
A14472-22 100g 390.00
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Pentafluoropropionic anhydride, 98%

MDL
MFCD00000429
EINECS
206-604-2

Chemical Properties

Formula
(CF3CF2CO)2O
Formula Weight
310.04
Boiling Point
73-74°
Density
1.589
Storage & Sensitivity
Moisture Sensitive. Ambient temperatures.
Solubility
Reacts with water.

Applications

Pentafluoropropionic anhydride act as a derivatising agent of amines and alcohols. It is used in the in preparation of halogenated derivatives of phenolic acids, required for determination of some biologically important acids in cerebrospinal fluid, as derivatization reagent in detection of 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain by GC-multiple ion detection and in simultaneous determination of the major metabolites of dopamine in rat striatum by gas-liquid chromatography.

Notes

Store at room temperature. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Literature References

E Watson.; S Wilk. Derivatization and gas chromatographic determination of some biologically important acids in cerebrospinal fluid. Analytical Biochemistry. 1974, 59 (2), 441-451.

M Kohno.; S Ohta.; M Hirobe. Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain. Biochemical and Biophysical Research Communications. 1986, 140 (1), 448-454.

Reagent for the preparation of volatile pentafluoropropionyl derivatives of amines, alcohols, etc. for GC, sensitive to electron-capture detection: J. Chromat., 60, 134 (1971); 69, 157 (1972); 97, 19, 175 (1974); Anal. Chem., 56, 1695 (1984). For monographs on GC reagents, see: D. R. Knapp, Handbook of Analytical Derivatisation Reactions, Wiley, N.Y. (1979); Handbook of Derivatives for Chromatography, 2nd ed., K. Blau and J. M. Halket, Eds., Wiley, Chichester (1993).

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H332-H335

Causes severe skin burns and eye damage. Harmful if inhaled. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1806446
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2915.90
TSCA
Yes

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