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356-42-3 - Pentafluoropropionic anhydride, 98% - Perfluoropropionic anhydride - A14472 - Alfa Aesar

A14472 Pentafluoropropionic anhydride, 98%

CAS Number
356-42-3
Synonyms
Perfluoropropionic anhydride

Size Price ($) Quantity Availability
5g 24.32
25g 96.30
100g 305.60
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Pentafluoropropionic anhydride, 98%

MDL
MFCD00000429
EINECS
206-604-2

Chemical Properties

Formula
(CF3CF2CO)2O
Formula Weight
310.04
Boiling Point
73-74°
Density
1.589
Sensitivity
Moisture Sensitive
Solubility
Reacts with water.

Applications

Pentafluoropropionic anhydride act as a derivatising agent of amines and alcohols. It is used in the in preparation of halogenated derivatives of phenolic acids, required for determination of some biologically important acids in cerebrospinal fluid, as derivatization reagent in detection of 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain by GC-multiple ion detection and in simultaneous determination of the major metabolites of dopamine in rat striatum by gas-liquid chromatography.

Notes

Store at room temperature. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Literature References

E Watson.; S Wilk. Derivatization and gas chromatographic determination of some biologically important acids in cerebrospinal fluid. Analytical Biochemistry. 1974, 59 (2), 441-451.

M Kohno.; S Ohta.; M Hirobe. Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain. Biochemical and Biophysical Research Communications. 1986, 140 (1), 448-454.

Reagent for the preparation of volatile pentafluoropropionyl derivatives of amines, alcohols, etc. for GC, sensitive to electron-capture detection: J. Chromat., 60, 134 (1971); 69, 157 (1972); 97, 19, 175 (1974); Anal. Chem., 56, 1695 (1984). For monographs on GC reagents, see: D. R. Knapp, Handbook of Analytical Derivatisation Reactions, Wiley, N.Y. (1979); Handbook of Derivatives for Chromatography, 2nd ed., K. Blau and J. M. Halket, Eds., Wiley, Chichester (1993).

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1806446
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2915.90
TSCA
Yes

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