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614-16-4 - Benzoylacetonitrile, 98+% - omega-Cyanoacetophenone - beta-Oxohydrocinnamonitrile - A14473 - Alfa Aesar

A14473 Benzoylacetonitrile, 98+%

CAS Number
614-16-4
Synonyms
omega-Cyanoacetophenone
beta-Oxohydrocinnamonitrile

Size Price ($) Quantity Availability
5g 40.90
25g 164.00
100g 573.00
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Benzoylacetonitrile, 98+%

MDL
MFCD00001942
EINECS
210-369-1

Chemical Properties

Formula
C9H7NO
Formula Weight
145.16
Melting point
79-83°
Boiling Point
159-160°/10mm
Solubility
Slightly soluble in water.

Applications

Benzoylacetonitrile is used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is also used in the synthesis of substituted naphtho[1,8-bc]pyrans and as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Literature References

L P Davies.; S C Chow.; J H Skerritt.; D J Brown.; G A Johnston. Pyrazolo[3,4-d]pyrimidines as adenosine antagonists.. Life Sciences. 1984, 34 (22), 2117-2128.

Tarek S. Mansour. Hunig's base-magnesium chloride mediated carbon alkylation and oxygen acylation of benzoylacetonitrile. Tetrahedron Letters. 1988, 29 (28), 3437-3440.

Active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines: Synthesis, 775 (1989). Reaction with tosic anhydride, followed by diethyl aminomalonate provides a short, facile synthesis of 3-aminopyrrole-2-carboxylates: J. Org. Chem., 65, 2603 (2000):

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
386745
Packing Group
III
Harmonized Tariff Code
2926.90
TSCA
Yes

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