I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Wittig reaction (see Appendix 1) with aldehydes, using K2CO3 in toluene, gives dienes: Synth. Commun., 22, 1421 (1992). The derived phosphorane also reacts with ß-chloroacrylates to give conjugated phosphoranes, convertible to trienes: Tetrahedron Lett., 1359 (1975):/n
Michael addition of the phosphorane to ɑß-unsaturated ketones, followed by intramolecular Wittig reaction, gives cyclohexa-1,3-dienes: Tetrahedron Lett., 4425 (1973). Further lithiation of the phosphorane in the presence of TMEDA, followed by reaction of the ylide anion with an aldehyde, provides a route to (E,E)-ß-hydroxy-1,3-dienes: Tetrahedron Lett., 32, 4353 (1991)./n
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.