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2,6-Dimethylaniline is used in pharmaceuticals, as dye intermediates and in organic synthesis. It is also used in the production of antioxidants, agricultural, pharmaceutical, rubber chemicals and other target organic molecules.
Hindered aromatic amines do not form imines by direct reaction with benzophenones. An indirect route involves formation of the imine with an aldehyde, introduction of the second aryl group by 1,2-addition of the aryllithium and dehydrogenation of the resulting secondary amine with DDQ: J. Org. Chem., 54, 2464 (1989).<
Huang, W. C.; Lin, Y. C. ; Tzeng, W. B. Mass-analyzed threshold ionization spectroscopy of 2,6-dimethylaniline, 2,6-dimethylaniline-NHD, and 2,6-dimethylaniline-ND2. Chem. Phys. Lett. 2012, 551, 50-53.
Ting, W-P.; Huang, Y-H.; Lu, M-C. Oxidation of 2,6-dimethylaniline by the Fenton, electro-Fenton and photoelectro-Fenton processes. J. Environ. Sci. Health, Part A 2011, 46 (10), 1085-1091.
Gockel, S. N.; Hull, K. L. Chloroform as a Carbon Monoxide Precursor: In or Ex Situ Generation of CO for Pd-Catalyzed Aminocarbonylations. Org. Lett. 2015, 17 (13), 3236-3239.
Yao, Q.; Wang, Z.; Zhang, Y.; Liu, X.; Lin, L.; Feng, X. N,N'-Dioxide/Gadolinium(III)-Catalyzed Asymmetric Conjugate Addition of Nitroalkanes to α, β-Unsaturated Pyrazolamides. J. Org. Chem. 2015, 80 (11), 5704-5712.
Hazard Statements: H227-H302-H312-H315-H319-H335-H351
Combustible liquid. Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Suspected of causing cancer.
Precautionary Statements: P201-P202-P210-P235-P261-P264b-P270-P271-P280i-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P330-P332+P313-P337+P313-P362-P370+P378q-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant