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3-(p-Tolyl)propionic acid was used during the coupling of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide with 4,5-diphenyl-2-(2-p-tolyl-ethyl)-4,5-dihydro-1H-imidazole resin.
Gregory H Merriman; Liang Ma; Patrick Shum, Daniel McGarry; Frank Volz; Jeffrey S Sabol; Alexandre Gross; Zhicheng Zhao; David Rampe; Lin Wang; Friederike Wirtz-Brugger; Bruce A Harris; Douglas Macdonald. Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 2005, 15 (2), 435-438.
Michael P. Johnson; Stewart P. Frescas; Robert Oberlender; David E. Nichols. Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: similarities to 3,4-(methylenedioxy)methamphetamine (MDMA). J. Med. Chem. 1991, 34 (5), 1662-1668.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.