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2-Butyne-1,4-diol is used as a precursor to prepare 1,4-butanediol, 2-butene-1,4-diol and mucochloric acid. It is also used in textile additives, corrosion inhibitors, plasticizers, synthetic resins and polyurethanes. It is an important raw material of vitamin B6. Further, it is used for brightening, preserving and inhibiting nickel plating. In addition, it is used in biological studies for nematocidal activity.
Undergoes an interesting trans-addition reaction with Grignard reagents: Chem. Lett., 765 (1984):
Kotha, S.; Ali, R. Diversity-oriented approach to intricate bis-armed spirocycles involving a two directional [2+ 2+ 2] co-trimerization and the [4+ 2] cycloaddition reaction as key steps. Tetrahedron Lett. 2015, 56 (17), 2172-2175.
Elchaninov, M. M.; Pyatnitsyna, E. V.; Elchaninov, I. M. Step mechanism of 1-butanol formation in the course of liquid-phase catalytic hydrogenation of 2-butyne-1, 4-diol. Russ. J. Appl. Chem. 2015, 88 (4), 585-589.
Hazard Statements: H301-H311-H314-H317-H331-H335-H373
Toxic if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. May cause an allergic skin reaction. Toxic if inhaled. May cause respiratory irritation. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P264b-P270-P271-P272-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant