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Methyl carbazate was used in the preparation of methyl 3-(4-methyl-benzyl-idene)carbazate. It was also used in the synthesis of imidazo[1,5-d][1,2,4]triazines. It is used as pharmaceutical intermediate.
Matsuo Nonoyama. Pyrrole ring cyclopalladation of hydrazones derived from N-(p-toluenesulfonyl)-3-acetylpyrrole with acetylhydrazine, methyl carbazate and semicarbazide. Inorganica Chimica Acta. 1988, 145, (1),53-56
R.Truhaut; R.Ferrando; J.M.Faccini; A.M.Monro. Negative results of carcinogenicity bioassay of methyl carbazate in rats: significance for the toxicological evaluation of carbadox. Toxicology. 1981, 22, (3),219-221
Can be used in a sequence for converting ketones to homologated nitriles: Org. Synth. Coll:, 6, 334 (1988):
Alternatively, reaction of the diazene intermediate with MeI and LiOMe yields the ɑ-methylnitrile: J. Org. Chem., 42, 2001 (1977).
Hazard Statements: H301-H315-H319-H335
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.