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6294-89-9 - Methyl carbazate, 98% - Methoxycarbonylhydrazine - Methyl hydrazinocarboxylate - A14548 - Alfa Aesar

A14548 Methyl carbazate, 98%

CAS Number
6294-89-9
Synonyms
Methoxycarbonylhydrazine
Methyl hydrazinocarboxylate

Size Price ($) Quantity Availability
100g 54.38
500g 149.40
2500g 608.62
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Methyl carbazate, 98%

MDL
MFCD00007594
EINECS
228-560-3

Chemical Properties

Formula
C2H6N2O2
Formula Weight
90.08
Melting point
70-73°
Solubility
Soluble in water.

Applications

Methyl carbazate was used in the preparation of methyl 3-(4-methyl-benzyl-idene)carbazate. It was also used in the synthesis of imidazo[1,5-d][1,2,4]triazines. It is used as pharmaceutical intermediate.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

Matsuo Nonoyama. Pyrrole ring cyclopalladation of hydrazones derived from N-(p-toluenesulfonyl)-3-acetylpyrrole with acetylhydrazine, methyl carbazate and semicarbazide. Inorganica Chimica Acta. 1988, 145, (1),53-56

 

R.Truhaut; R.Ferrando; J.M.Faccini; A.M.Monro. Negative results of carcinogenicity bioassay of methyl carbazate in rats: significance for the toxicological evaluation of carbadox. Toxicology. 1981, 22, (3),219-221

Can be used in a sequence for converting ketones to homologated nitriles: Org. Synth. Coll:, 6, 334 (1988):

Alternatively, reaction of the diazene intermediate with MeI and LiOMe yields the ɑ-methylnitrile: J. Org. Chem., 42, 2001 (1977).

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1679395
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2928.00
TSCA
Yes

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