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Tetraethyl (dimethylaminomethylene)diphosphonate undergoes Horner-Wadsworth-Emmons olefination with an aldehyde gives the ?-phosphonato enamine, readily convertible to the homologous acid.
Ch. Siva Kesava Raju; M.S. Subramanian.DAPPA grafted polymer: an efficient solid phase extractant for U(VI), Th(IV) and La(III) from acidic waste streams and environmental samples. Talanta. 2005, 67 (1), 81-89.
David Portet; Benoît Denizot; Elmar Rump; François Hindre; Jean-Jacques Le Jeune and Pierre Jallet. Comparative biodistribution of thin-coated iron oxide nanoparticles TCION: Effect of different bisphosphonate coatings. Drug Development Research. 2001, 54 (4), 173-181.
Horner-Wadsworth-Emmons olefination with an aldehyde gives the ɑ-phosphonato enamine, readily convertible to the homologous acid: Angew. Chem. Int. Ed., 7, 391 (1968); Synth. Commun., 12, 415 (1982):
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.