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Sodium trifluoroacetate is used in acid catalyzed reactions. It is also used as an intermediate for active pharmaceutical ingredients (API). Further, it acts as a precursor for the trifluoromethylation of aldehydes using copper(I) halide as a catalyst.
Carbene precursor, compare Sodium chlorodifluoroacetate, A15756.
In the presence of CuI, converts aryl iodides to benzotrifluorides: Chem. Lett., 1719 (1981); J. Chem. Soc., Perkin 1, 921 (1988).
Chan, K. S. L.; Fu, H. Y.; Yu, J. Q. Palladium(II)-Catalyzed Highly Enantioselective C-H Arylation of Cyclopropylmethylamines. J. Am. Chem. Soc. 2015, 137 (5), 2042-2046.
Castano, M.; Seo, K. S.; Guo, K.; Becker, M. L.; Wesdemiotis, C.; Puskas, J. E. Green polymer chemistry: synthesis of symmetric and asymmetric telechelic ethylene glycol oligomers. Polym. Chem. 2015, 6 (7), 1137-1142.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.