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Thiophene-3-carboxaldehyde has been used in the synthesis of series of 4-substituted 2-thiophenesulfonamides, acetal and ketal derivatives of 4?-demethylepipodophyllotoxin-β-D-glucoside and epipodophyllotoxin-β-D-glucoside. Also has been used to produce 1,2-di-3-thienyl-2-hydroxyethanone (3,3?-thenoin), 3-thienyl symmetric analog of benzoin.
J.M.Holmes; G.C.Lee; M.Wijono; R.Weinkam; L.A.Wheeler; M.E.Garst. Synthesis and carbonic anhydrase inhibitory activity of 4-substituted 2-thiophenesulfonamides. Journal of Medicinal Chemistry. 1994, 37, (11),1646-1651
R.S.Gupta; P.C.Chenchaiah; R.Gupta. Synthesis and structure-activity relationships among glycosidic derivatives of 4'-demethylepipodophyllotoxin and epipodophyllotoxin, showing VM26- and VP16-213-like activities. Anti-cancer drug design. 1987, 2, (1),1-12
Hazard Statements: H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.