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Thiophene-3-carboxaldehyde has been used in the synthesis of series of 4-substituted 2-thiophenesulfonamides, acetal and ketal derivatives of 4?-demethylepipodophyllotoxin-β-D-glucoside and epipodophyllotoxin-β-D-glucoside. Also has been used to produce 1,2-di-3-thienyl-2-hydroxyethanone (3,3?-thenoin), 3-thienyl symmetric analog of benzoin.
J.M.Holmes; G.C.Lee; M.Wijono; R.Weinkam; L.A.Wheeler; M.E.Garst. Synthesis and carbonic anhydrase inhibitory activity of 4-substituted 2-thiophenesulfonamides. Journal of Medicinal Chemistry. 1994, 37, (11),1646-1651
R.S.Gupta; P.C.Chenchaiah; R.Gupta. Synthesis and structure-activity relationships among glycosidic derivatives of 4'-demethylepipodophyllotoxin and epipodophyllotoxin, showing VM26- and VP16-213-like activities. Anti-cancer drug design. 1987, 2, (1),1-12
Hazard Statements: H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P260-P201-P280a-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.