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Phenylhydrazine hydrochloride is used as a selective mannosidase inhibitor. It is used in the study of tyrosine phosphorylation of janus protein tyrosine kinase in the EPO-responsive normal erythroblastoid cells of anemic mice. It is used in steroid assays and as an N-protecting reagent. Its free base, phenylhydrazine is used to prepare indoles, which find application as intermediates in the synthesis of various dyes and pharmaceuticals.
Butin, A. V.; Uchuskin, M. G.; Pilipenko, A. S.; Serdyuk, O. V.; Trushkov, I. V. Unusual reactivity of beta-(3-indolyl)-alpha, beta-unsaturated ketones. 2-Acetylvinyl group removal by phenylhydrazine hydrochloride. Tetrahedron Lett. 2011, 52 (41), 5255-5258.
Muralirajan, K.; Haridharan, R.; Prakash, S.; Cheng, C. H. Rhodium(III)-Catalyzed in situ Oxidizing Directing Group-Assisted C? H Bond Activation and Olefination: A Route to 2-Vinylanilines. Adv. Synth. Catal. 2015, 357, (4), 761-766.
Hazard Statements: H301-H311-H331-H315-H319-H317-H341-H350-H372
Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. Suspected of causing genetic defects. May cause cancer. Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P201-P301+P310a-P305+P351+P338-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.