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144-48-9 - 2-Iodoacetamide, 98%, stab. with ca 5-8% water - A14715 - Alfa Aesar

A14715 2-Iodoacetamide, 98%, stab. with ca 5-8% water

CAS Number
144-48-9
Synonyms

Size Price ($) Quantity Availability
5g 21.45
25g 63.12
100g 204.97
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2-Iodoacetamide, 98%, stab. with ca 5-8% water

MDL
MFCD00008028
EINECS
205-630-1

Chemical Properties

Formula
ICH2CONH2
Formula Weight
184.96
Melting point
92-95°(dried)
Sensitivity
Light Sensitive
Solubility
Soluble in water, dimethyl formamide and ethanol. Slightly soluble in methanol.

Applications

Alkylating agent used in peptide mapping because it covalently binds with the thiols in cysteine to prevent disulfide bond formation2-Iodoacetamide is used as an electrophile for covalent modification of nucleophilic residues on proteins such as cysteine, methionine and histidine. It is used to bind with thiol group of cysteine, thereby it protects the formation disulfide bonds. It is involved as an inhibitor of deubiquitinase enzymes (DUBs). Further, it acts as an alkylating sulfhydryl reagent.

Notes

Store in a cool place. Light and moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.

Literature References

Zbancioc, G.; Mangalagiu, I. I.; Moldoveanu, C. Ultrasound assisted synthesis of imidazolium salts: An efficient way to ionic liquids. Ultrason. Sonochem. 2015, 23, 376-384.

Moriyama, M.; Metzger, S.; van der Vlies, A. J.; Uyama, H.; Ehrbar, M.; Hasegawa, U. Inhibition of Angiogenesis by Antioxidant Micelles. Adv. Healthcare Mater. 2013, 4 (4), 569-575.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H317-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.

Precautionary Statements: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P363-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1739080
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2924.19
TSCA
Yes
RTECS
AC4200000

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