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A14740 Dichloroacetic acid, 99%

CAS Number
79-43-6
Synonyms

Stock No. Size Price ($) Quantity Availability
A14740-22 100g 23.80
A14740-36 500g 42.60
A14740-0E 2500g 133.00
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Dichloroacetic acid, 99%

MDL
MFCD00004223
EINECS
201-207-0

Chemical Properties

Formula
Cl2CHCO2H
Formula Weight
128.94
Melting point
9-11°
Boiling Point
192-194°
Flash Point
>110°(230°F)
Density
1.564
Refractive Index
1.4620
Storage & Sensitivity
Hygroscopic. Ambient temperatures.
Solubility
Miscible with water, ethanol, diethyl ether, n-octanol and acetone.

Applications

Dichloroacetic acid salts are used as drugs due to its inhibition of the enzyme pyruvate dehydrogenase kinase. It is also employed to stem the production of lactic acid to treat lactic acidosis. It is clinically essential in children to treat lactic acidosis.

Notes

Incompatible with strong oxidizing agents, strong bases and strong reducing agents.

Literature References

Moderately strong acid which has been recommended for the catalysis of mixed acetal formation by reaction of alcohols with Ethyl­ vinyl­ ether, A15691 . Has also been used as an acid catalyst and deprotecting agent in various other applications including peptide synthesis.

Ding, Y.; Zhu, J.; Ji, D.; Cao, Y.; Ling, X.; Chen, W. Enhancing adsorption efficiency of dichloroacetic acid onto mesoporous carbons: Procedure optimization, mechanism and characterization. J. Colloid Interface Sci. 2015, 452, 134-140.

Scialdone, O.; Galia, A.; Sabatino, S.; Mira, D.; Amatore, C. Electrochemical Conversion of Dichloroacetic Acid to Chloroacetic Acid in a Microfluidic Stack and in a Series of Microfluidic Reactors. Chem. Electro. Chem. 2015, 2 (5), 684-690.

GHS Hazard and Precautionary Statements

Hazard Statements: H290-H311-H314-H351-H360-H362-H373

May be corrosive to metals. Toxic in contact with skin. Causes severe skin burns and eye damage. Suspected of causing cancer. May damage fertility or the unborn child. May cause harm to breast-fed children. May cause damage to organs through prolonged or repeated exposure.

Precautionary Statements: P201-P202-P234-P260-P263-P264b-P270-P271-P281-P284-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P390-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep only in original container. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid contact during pregnancy/while nursing. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. Wear respiratory protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Absorb spillage to prevent material damage. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,3050
Beilstein
1098596
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2915.40
TSCA
Yes
RTECS
AG6125000

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