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922-67-8 - Methyl propiolate, 99% - Methyl acetylenecarboxylate - Propiolic acid methyl ester - A14743 - Alfa Aesar

A14743 Methyl propiolate, 99%

CAS Number
922-67-8
Synonyms
Methyl acetylenecarboxylate
Propiolic acid methyl ester

Size Price ($) Quantity Availability
5g 46.14
25g 173.04
100g 537.30
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Methyl propiolate, 99%

MDL
MFCD00008572
EINECS
213-083-5

Chemical Properties

Formula
HC≡CCO2CH3
Formula Weight
84.07
Boiling Point
98-101°
Flash Point
10°(50°F)
Density
1.016
Refractive Index
1.4080
Solubility
Not miscible in water.

Applications

Methyl propiolate was used in the synthesis of polysubstituted 3-arylaminoacrylate and tetrahydropyrimidin-2-one derivatives. It was also used as a thiol derivatizing agent for capillary electrophoresis.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

Eirini-Chrysanthi Tsardaka; Constantinos K.Zacharis; Paraskevas D.Tzanavaras; Anastasia Zotou. Determination of glutathione in baker's yeast by capillary electrophoresis using methyl propiolate as derivatizing reagent. Journal of chromatography. A 2013, 1300, 204-208

 

Thomas G.Back; M.Vijaya Krishna. Free-radical additions of diselenides to dimethyl acetylenedicarboxylate, methyl propiolate and dimethyl maleate. J. Org. Chem. 1988, 53, (11),2533-2536

For the conjugate addition of nitro-compounds, catalyzed by F-, see Nitroethane, A10855. For further reactions of propiolate esters, see Ethyl­ propiolate, A15068.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H315-H319-H335

Highly flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
605462
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2916.19
TSCA
No
RTECS
UE0050000

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