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2-Picolinic acid is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.
Hong Zhao; Yuzhong Zhang; Zhuobin Yuan. Electrochemical determination of dopamine using a poly(2-picolinicacid) modified glassy carbon electrode. Analyst. 2001, 126, (3),358-360
Xinjian Li; Dapeng Zou; Faqiang Leng; Chunxia Sun; Jingya Li; Yangjie Wu; Yusheng Wu. Arylation of 2-substituted pyridines via Pd-catalyzed decarboxylative cross-coupling reactions of 2-picolinic acid. Chemical Communications. 2013, 49, (3),312-314
Has been found to accelerate significantly oxidations with chromic acid: J. Am. Chem. Soc., 98, 1026 (1976).
Amino groups can be protected, by DCC coupling, as picolinamides, which can be cleaved with acidic Cu(OAc)2: Synth. Commun., 383 (1972).
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.