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4376-18-5 - Methyl hydrogen phthalate, 97% - Benzene-1,2-dicarboxylic acid monomethyl ester - Monomethyl phthalate - A14780 - Alfa Aesar

A14780 Methyl hydrogen phthalate, 97%

CAS Number
4376-18-5
Synonyms
Benzene-1,2-dicarboxylic acid monomethyl ester
Monomethyl phthalate

Size Price ($) Quantity Availability
10g 46.17
50g 154.39
250g 501.82
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Methyl hydrogen phthalate, 97%

MDL
MFCD00002466
EINECS
224-476-6

Chemical Properties

Formula
C9H8O4
Formula Weight
180.16
Melting point
81-84°
Solubility
Insoluble in water.

Applications

Methyl hydrogen phthalate is used as a phthalate ester metabolite, linked to precocious puberty.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

ML Bender.; F Chloupek.; MC Neveu. Intramolecular Catalysis of Hydrolytic Reactions. III. Intramolecular Catalysis by Carboxylate Ion in the Hydrolysis of Methyl Hydrogen Phthalate1, 2. J. Am. Chem. Soc.1958, 80 (20), 5384-5387.

V Rao.; PV Ashokan.; MH Shridhar. Studies on the compatibility and specific interaction in cellulose acetate hydrogen phthalate(CAP) and poly methyl methacrylate (PMMA) blend. Polymer.1999, 40 (25), 7167-7171.

Undergoes a modified Curtius rearrangement via a mixed anhydride. The resulting isocyanate has been cyclized with, e.g. alanine to give chiral quinazoline-2,4-dione derivatives: Heterocycles, 36, 1305 (1993):

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2048766
Harmonized Tariff Code
2917.34
TSCA
No

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