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A14780 Methyl hydrogen phthalate, 97%

CAS Number
4376-18-5
Synonyms
Benzene-1,2-dicarboxylic acid monomethyl ester
Monomethyl phthalate

Stock No. Size Price ($) Quantity Availability
A14780-09 10g 45.90
A14780-18 50g 152.00
A14780-30 250g 557.00
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Methyl hydrogen phthalate, 97%

MDL
MFCD00002466
EINECS
224-476-6

Chemical Properties

Formula
C9H8O4
Formula Weight
180.16
Melting point
81-84°
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water.

Applications

Methyl hydrogen phthalate is used as a phthalate ester metabolite, linked to precocious puberty.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

ML Bender.; F Chloupek.; MC Neveu. Intramolecular Catalysis of Hydrolytic Reactions. III. Intramolecular Catalysis by Carboxylate Ion in the Hydrolysis of Methyl Hydrogen Phthalate1, 2. J. Am. Chem. Soc.1958, 80 (20), 5384-5387.

V Rao.; PV Ashokan.; MH Shridhar. Studies on the compatibility and specific interaction in cellulose acetate hydrogen phthalate(CAP) and poly methyl methacrylate (PMMA) blend. Polymer.1999, 40 (25), 7167-7171.

Undergoes a modified Curtius rearrangement via a mixed anhydride. The resulting isocyanate has been cyclized with, e.g. alanine to give chiral quinazoline-2,4-dione derivatives: Heterocycles, 36, 1305 (1993):

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2048766
Harmonized Tariff Code
2917.34
TSCA
No

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