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Methylphosphonic dichloride is used for the preparation of oligonucleotides. It is also used in Suzuki reaction. It serves as a precursor to several chemical weapon agents. Further, it reacts with hydrogen fluoride to get methylphosphonyl difluoride which is used in the production of sarin and soman nerve agents. In addition to this, it undergoes condensation reactions with aminobenzenes and alcohols.
Precursor of bis(2,2,2-trifluoroethyl) carboxymethylphosphonate, a useful intermediate for the Horner-Wadsworth-Emmons synthesis of (Z)-acrylates: Tetrahedron Lett., 24, 4405 (1983); Org. Synth. Coll., 9, 88 (1998).
Hoang, D.; Kim, W.; An, H.; Kim, J. Flame retardancies of novel organo-phosphorus flame retardants based on DOPO derivatives when applied to ABS. Macromol. Res. 2015, 23 (5), 442-448.
Steinbach, T.; Wahlen, C.; Wurm, F. R. Poly(phosphonate)-mediated Horner-Wadsworth-Emmons reactions. Polym. Chem. 2015, 6 (7), 1192-1202.
Hazard Statements: H330-H314-H318
Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P303+P361+P353-P304+P340-P305+P351+P338-P320-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.