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4659-45-4 - 2,6-Dichlorobenzoyl chloride, 98% - A14839 - Alfa Aesar

A14839 2,6-Dichlorobenzoyl chloride, 98%

CAS Number
4659-45-4
Synonyms

Size Price ($) Quantity Availability
10g 40.43
50g 162.00
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2,6-Dichlorobenzoyl chloride, 98%

MDL
MFCD00000662
EINECS
225-102-4

Chemical Properties

Formula
C7H3Cl3O
Formula Weight
209.46
Melting point
15-18°
Boiling Point
130-132°/15mm
Flash Point
>110°(230°F)
Density
1.463
Refractive Index
1.5600
Sensitivity
Moisture Sensitive
Solubility
Miscible with alcohol, ether and acetone. Slightly miscible with heptane. Immiscible with water.

Applications

2,6-Dichlorobenzoyl chloride acts as an important intermediate in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is employed in the substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases. It is also used in the preparation of 1-acyliridoles and (-)-aspicilin. In addition to this, it undergoes esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.

Notes

Moisture sensitive. Incompatible with alcohols, oxidizing agents and strong bases.

Literature References

Furse, S.; Mak, L.; Tate, E. W.; Templer, R. H.; Ces, O.; Woscholski, R.; Gaffney, P. R. Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity. Org. Biomol. Chem. 2015, 13 (7), 2001-2011.

Zhang, T.; Paluch, K.; Scalabrino, G.; Frankish, N.; Healy, A. M.; Sheridan, H. Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol. J. Mol. Struct. 2015, 1083, 286-299.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
639531
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2916.39
TSCA
No

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