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4-Methoxyphenol is an active ingredient and used in dermatology. It is employed as a pharmaceutical drug in skin depigmentation. It is used as polymerization inhibitors. For example, in the radical polymerization of acryaltes and styrene monomers. It is also used as an intermediate in the preparationagrochemicals, liquid crystals. It acts as a stabilizer for the formulation of inks, toners and adhesives. It is mainly used as an additive for textile and leather industries.
For a study of the direct dilithiation of alkoxyphenols, see: J. Org. Chem., 55, 3902 (1990).
Primary OH groups can be protected as 4-methoxyphenyl ethers by Mitsunobu alkylation. These are stable to aqueous acid or base at 1000, high pressure hydrogenation, ozonolysis, LiAlH4, or Cr(VI) reagents. Deprotection can be effected with CAN: Tetrahedron Lett., 26, 6291 (1985); 29, 1389 (1988), or anodic oxidation: Carbohydr. Res., 277, 321 (1995)./n
Swiech, O.; Mieczkowska, A.; Chmurski, K.; Bilewicz, R. Intermolecular Interactions between Doxorubicin and β-Cyclodextrin 4-Methoxyphenol Conjugates. J. Phys. Chem. B 2012, 116 (6), 1765-1771.
Wang, YH.; Avonto, C.; Avula, B; Wang, M.; Rua, D.; Khan, I. Quantitative Determination of alpha-Arbutin, beta-Arbutin, Kojic Acid, Nicotinamide, Hydroquinone, Resorcinol, 4-Methoxyphenol, 4-Ethoxyphenol, and Ascorbic Acid from Skin Whitening Products by HPLC-UV. J. AOAC Int. 2015, 98 (1), 5-12.
Hazard Statements: H302-H317-H319-H361d-H373-H500
Harmful if swallowed. May cause an allergic skin reaction. Causes serious eye irritation. Suspected of damaging the unborn child. May cause damage to organs through prolonged or repeated exposure. May form combustible dust concentrations in air
Precautionary Statements: P201-P202-P260-P264b-P270-P272-P280-P281-P301+P312-P302+P352-P305+P351+P338-P308+P313-P330-P333+P313-P337+P313-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation or rash occurs: If eye irritation persists: Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant