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Lithiation leads to products of metallation at the 3- and 2-methyl groups in that order, whereas attack at the 5-methyl, surprisingly, is disfavored. For a detailed study of lithiation with LDA, see: J. Org. Chem., 48, 2130 (1983). For subsequent reaction with trans-1,2-dichloroethylene to give isomeric pyrrolo[1,2-a]pyrazines, see: J. Heterocycl. Chem., 18, 445 (1981)./n
Hazard Statements: H226-H302-H315-H319-H335
Flammable liquid and vapour. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.