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4-Chlorophenyl isocyanate is used in the preparation of isothiocyanates. Aryl isocyanates undergo [2+2] cycloaddition reactions with dihydrofuran to give bicyclic ß-lactams in high yield.
Robert L. Metcalf.; Po-Yung. Lu.; Stephen. Bowlus. Degradation and environmental fate of 1-(2,6-difluorobenzoyl)-3-(4-chlorophenyl)urea. J. Agric. Food Chem. 1975, 23, (3), 359-364.
Aryl isocyanates undergo [2+2] cycloaddition reactions with dihydrofuran to give bicyclic ß-lactams in high yield: Nippon Kagaku Kaishi, 459 (1995):
For general chemistry of isocyanates, see Appendix 3.
Hazard Statements: H301-H330-H315-H318-H334-H335
Toxic if swallowed. Fatal if inhaled. Causes skin irritation. Causes serious eye damage. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.
Precautionary Statements: P301+P310a-P304+P340-P305+P351+P338-P320-P330-P405-P501a
IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.