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104-12-1 - 4-Chlorophenyl isocyanate, 98% - A14966 - Alfa Aesar

A14966 4-Chlorophenyl isocyanate, 98%

CAS Number
104-12-1
Synonyms

Size Price ($) Quantity Availability
5g 16.48
25g 33.75
100g 73.68
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4-Chlorophenyl isocyanate, 98%

MDL
MFCD00002024
EINECS
203-176-9

Chemical Properties

Formula
C7H4ClNO
Formula Weight
153.57
Melting point
29-31°
Boiling Point
203-204°
Flash Point
90°(194°F)
Density
1.200
Refractive Index
1.5618
Sensitivity
Moisture Sensitive
Solubility
Hydrolyzes in water.

Applications

4-Chlorophenyl isocyanate is used in the preparation of isothiocyanates. Aryl isocyanates undergo [2+2] cycloaddition reactions with dihydrofuran to give bicyclic ß-lactams in high yield.

Notes

Keep container tightly closed. Store away from oxidizing agents.

Literature References

Robert L. Metcalf.; Po-Yung. Lu.; Stephen. Bowlus. Degradation and environmental fate of 1-(2,6-difluorobenzoyl)-3-(4-chlorophenyl)urea. J. Agric. Food Chem. 1975, 23, (3), 359-364.

Aryl isocyanates undergo [2+2] cycloaddition reactions with dihydrofuran to give bicyclic ß-lactams in high yield: Nippon Kagaku Kaishi, 459 (1995):

For general chemistry of isocyanates, see Appendix 3.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H330-H315-H335-H334-H318-H400-H410

Toxic if swallowed. Fatal if inhaled. Causes skin irritation. May cause respiratory irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes serious eye damage. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects.

Precautionary Statements: P260-P284-P285-P301+P310-P304+P340-P305+P351+P338-P320-P330-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. In case of inadequate ventilation wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
386235
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2929.10
TSCA
Yes
RTECS
NQ8575000

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