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Reacts with ɑ-diketones in aqueous buffer to give bicyclic diketones (Weiss-Cook condensation): Tetrahedron Lett., 4885 (1968); Org. Synth. Coll., 7, 50 (1990):/n
See also: J. Chem. Soc., Perkin 1, 1425 (1997). Use of cyclic ɑ-diketones leads to propellanes: Can. J. Chem., 189 (1978)./n
The Na salt (NaH/THF) reacts with alkynals: J. Org. Chem., 62, 5688 (1997), or ynones: Synth. Commun., 28, 1525 (1998), under mild conditions to give 4-substituted dimethyl 2-hydroxyisophthalates via a Michael addition - aldol cyclization process; see 3-Butyn-2-one, L05527 for scheme./n
Hazard Statements: H317
May cause an allergic skin reaction.
Precautionary Statements: P261-P272-P280g-P302+P352-P333+P313-P363-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant